Vitamins play a remarkable role in nourishing and maintaining your body; their role is like a small part of the machine that plays a significant role in operating the machine safely and effectively. Likewise, all vitamins are essential to operate the human body actively and effectively. Thus, it would be best if you keep an eye on the level of all vitamins and minerals in your blood. 

What is methylfolate?

Methylfolate 5mg is the functional form of a water-soluble vitamin B9 (folate), which your body utilizes to carry out more than hundreds of biological mechanisms. It generates inside the body by transforming folate or folic acid into methylfolate with the support of the methylenetetrahydrofolate enzyme. 

Vegetables, especially green leaves and fruits, are abundant with folates. Additionally, fortified food and dietary products contain folic acid to prevent its deficiency. 

What is good in methylfolate?

Every nutrient that demands your body has its own worth and potential. Likewise, methylfolate exhibits inherent properties that make it most valuable among others. Let’s disclose this pandora box and see what is good in methylfolate.

Generation of neurotransmitters:

Methylfolate indirectly induces the generation of neurotransmitters (chemical messengers) in your body. It supports the formation of Tetrahydrobiopterin (BH4), a cofactor for the formation of serotonin, dopamine, and norepinephrine. These chemicals modulate your mood and are known as mood-swinging chemicals. 

Effective for the treatment of depression:

Methylfolate may prove a promising chemical as an adjunctive therapy to treat depression symptoms in children and adults. It can pass over the blood-brain barrier and invade the brain area to work out. A psychiatrist prescribes it with antipsychotic drugs to boost their effectiveness. Research studies observe that a low folate level causes mental issues, and psychiatric patients do not respond to antidepressant drugs. Thus, doctors advised using it with antidepressants medications. 

Recycling of Homocysteine:

Methylfolate metabolizes the conversion of homocysteine back into methionine and tries to cope with the homocysteine level in your blood. Homocysteine is produced as a by-product during the metabolism of methionine. High homocysteine level is the root of cardiovascular disorders that eventually lead to death. You should thank methylfolate.

Source of Methyl group:

Methylation is a demanding biological process that offers the biosynthesis of various chemicals; you can say an activation process through which thousands of chemicals activate and deactivate that works out for your body. A methyl group (CH3) is needed during methylation, and methylfolate is the primary source of the methyl group. 

Help in maintaining pregnancy:

Methylfolatealso plays a remarkable role in carrying out healthy pregnancy. It helps in conception and during the whole pregnancy. It induces the formation of new cells and promotes the baby’s growth. Methylfolate keeps the baby safe from spina bifida and anencephaly disorders. 

Produce healthy red blood cells

Methylfolate promotes the synthesis of new healthy red blood cells (RBC) that binds oxygen, circulate in the whole body, and provide oxygen to cells. Oxygen is required for respiration; RBC absorbs carbon dioxide from the cells to expel outside the body. Methylfolate deficiency causes the absence of RBC and eventually causes Anemia.

Blessing for patients with MTHFR gene mutation:

Methylfolate supplements are a blessing for patients with MTHFR defective gene. Their bodies may produce less MTHFR enzyme involved in folate conversion into methylfolate. The childbearing women with muted MTHFR gene, can use methylfolate supplements to maintain their pregnancy successfully. 

Above mentioned uses are surprising facts of methylfolate; however, its deficiency is responsible for many health issues. Think about it! 


Methylfolate is an active metabolite form of folate that is synthesized inside your body by the activity of the MTHFR enzyme. It will help if you read the surprising facts of methylfolate described above to estimate this chemical’s worth. It is essential in producing neurotransmitters, healthy red blood cells, DNA, RNA, chromosomes, etc.